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              首頁 > 產品 > 功能性抗體 > 抗小鼠低內毒素無疊氮鈉抗體

              LE/AF Purified Anti-Mouse CD8a Monoclonal Antibody M10085-14Bdatasheet

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              數據表

              • 概述

                LE/AF Purified Anti-Mouse CD8a Monoclonal Antibody

                The 2.43 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation induced by binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck and facilitate intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites. The 2.43 antibody is widely used as a phenotypic marker for mouse CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

                FCM,IF

                Mouse

              • 性能

                Liquid

                Keep as concentrated solution.Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at-20°C or lower. Avoid cycles of freezing and thawing.

                PBS, pH 7.2

                1mg/ml, >95% (by SDS-PAGE)

                Rat IgG2b

              • 應用

                This 2.43 antibody has been reported for use in flow cytometric staining. It has also been reported for use in cell depletion.

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